Charline Miot Elucidating the involvement of DNA double-strand breaks in the genesis of lymphoid cancers
Charline Miot, post-doctoral fellow, Children's Hospital of Philadelphia Research Institute, Perelman School of Medicine, University of Pennsylvania (United States), under the supervision of Professor Craig Bassing.
- 2018 • Bettencourt Prize for Young Researchers
The 2018 Bettencourt Prize for Young Researchers rewards Charline Miot, post-doctoral researcher, for her research on lymphoid cancers.
Outsmarting leukemia by combining medicine and fundamental research
A former student at the Inserm Liliane Bettencourt School, Charline Miot is a specialist in pediatric oncology. During her doctorate in science, she revealed the role of several cytokines, immune signaling molecules, in the context of infection by the hepatitis C virus. These results shed light on a process of chronic infection which, at term, leads to the development of carcinomas.
Identify new therapeutic targets
His postdoctoral work will lead him to study in mice a mechanism of double-stranded DNA breaks involved in the translocation of genes leading to the overexpression of oncogenic proteins. The results of this work could allow the identification of therapeutic targets, particularly in the context of lymphoid cancers such as acute childhood leukemia.
Charline Miot in a few words
SCIENCE THESIS: “Role of innate immune cytokines IL-26 and M-CSF/IL-34 in hepatitis C virus infection”, under the supervision of Professor Pascale Jeannin, CHU d'Angers, Doctoral School of Biology health - Specialty Immunology, University of Angers.
MEDICINE THESIS: "Osteoarticular complications during the treatment of acute lymphoblastic leukemia in children", under the direction of Professor Isabelle Pellier, University of Angers.
POST DOCTORATE : "Study of the mechanisms and the role of DNA double-strand breaks in the negative feedback of V(D)J recombinations - Implications in the oncogenesis of lymphoid cancers", under the supervision of Professor Craig Bassing, Children's Hospital of Philadelphia Research Institute, Perelman School of Medicine, University of Pennsylvania (USA).
Bettencourt Prize for Young Researchers
Created in 1990, the Bettencourt Prize for Young Researchers is one of the first initiatives of the Fondation Bettencourt Schueller. Until 2021, this prize was awarded each year to 14 young doctors of science or doctors of medicine, to enable them to carry out their post-doctoral stay in the best foreign laboratories. 349 young researchers were distinguished. The prize endowment was €25,000.
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